Comparison of Intravenous Dexamethasone and Dexmedetomidine for Spinal Anesthesia Quality in Opium-Addicted Patients: A Parallel Double-Blind Randomized Clinical Trial

Background: Spinal anesthesia (SA) is a frequently used method by anesthesiologists in patients who may not need general or have contraindication for applying anesthesia. Nevertheless, numerous contemplations to be considered when using this method. Objectives: We compared the effect of intravenous (IV) administration dexamethasone versus dexmedetomidine alongside subarachnoid injection Bupivacaine terms spinal quality opium-addicted patients. Patients and Methods: This parallel randomized clinical trial (RCT) was conducted on aged 18 65 with The American Society Anesthesiologists (ASA) class I/II candidates surgery under SA. In one group, at dose 0.5 μg/kg body weight injected intravenously 10 minutes before then during surgery. another 8 mg surgery, normal saline rate μg/kg/h infused primary outcomes were onset sensory block, motor regression two levels duration block. secondary total analgesia time first requirement. Results: Totally, 57 divided into groups included final analysis. results showed that differed significantly none assessed baseline variables (P > 0.05). mean between performing SA block Dexamethasone Dexmedetomidine 4.8 ± 2.2 4.2 1.9 minutes, respectively = 0.290). 5.9 2.6 5.1 2.3 0.251). 63.6 27.7 82.0 17.1 0.004). 75.0 32.1 97.5 19.4 0.377). 86.9 32.9 109.3 16.3 0.002). requirement analgesic agent 206.21 93.19 267.86 76.02 0.008). Conclusions: It seems received concurrent IV better than those dexamethasone.